Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation
نویسندگان
چکیده
منابع مشابه
Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation.
Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has been found to spontaneously develop neuropathological signs of AD, including amyloid-β (Aβ) and tau deposits, as well as a decline in cognition with age. Firstly, the present work introduces a novel behavioral assessment for O. degus - the b...
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To examine if a feature of episodic-like memory reported in rats is shared with other species, we investigated whether degus would form an integrated memory of object (what), place (where), and context (which). We used two E-shaped mazes with different contexts regarding the wall and the floor. Degus were entered into the middle arm and first explored the maze with two trial-unique objects plac...
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Wheel-running and other non-photic stimuli influence the rest-activity pattern of diurnal and nocturnal mammals. A day to night inversion of phase preference of activity was described among Octodon degus, when exposed to ad-libitum wheel running. We have studied the rest-activity pattern response in presence of ad libitum wheel-running in wild-captured male individuals from two species of genus...
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Alzheimer's disease primarily occurs as sporadic disease and is accompanied with vast socio-economic problems. The mandatory basic research relies on robust and reliable disease models to overcome increasing incidence and emerging social challenges. Rodent models are most efficient, versatile, and predominantly used in research. However, only highly artificial and mostly genetically modified mo...
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A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major retinorecipient nuclei as well as in the DRN and periaqueductal gray (PAG) of t...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2015
ISSN: 1567-2050
DOI: 10.2174/1567205012666150324181652